An essential role for a CD36-related receptor in pheromone detection in Drosophila

@article{Benton2007AnER,
  title={An essential role for a CD36-related receptor in pheromone detection in Drosophila},
  author={Richard Benton and Kirsten S. Vannice and Leslie B. Vosshall},
  journal={Nature},
  year={2007},
  volume={450},
  pages={289-293}
}
The CD36 family of transmembrane receptors is present across metazoans and has been implicated biochemically in lipid binding and transport. Several CD36 proteins function in the immune system as scavenger receptors for bacterial pathogens and seem to act as cofactors for Toll-like receptors by facilitating recognition of bacterially derived lipids. Here we show that a Drosophila melanogaster CD36 homologue, Sensory neuron membrane protein (SNMP), is expressed in a population of olfactory… Expand
SNMP is a signaling component required for pheromone sensitivity in Drosophila
TLDR
It is shown that SNMP function is consistent with a direct role in cVA signal transduction, and pheromone perception in Drosophila should serve as an excellent model to elucidate the role of CD36 members in transmembrane signaling. Expand
A CD36 ectodomain mediates insect pheromone detection via a putative tunnelling mechanism
TLDR
A model in which SNMP1 funnels hydrophobic pheromones from the extracellular fluid to integral membrane receptors is proposed, in which this ectodomain is essential, but intracellular and transmembrane domains dispensable, for cilia localization and phersomone-evoked responses. Expand
Volatile pheromone signalling in Drosophila
TLDR
Identification and functional dissection of these factors in Drosophila melanogaster Meigen should permit the identification of homologous factors in pathogenic insects and agricultural pests, which, in turn, may be viable candidates for novel classes of compounds to control populations of target insect species without impacting beneficial species. Expand
Lipid flippase modulates olfactory receptor expression and odorant sensitivity in Drosophila
TLDR
It is shown that Or67d neurons are severely affected, with strongly impaired cVA-induced responses and lacking spontaneous spiking in the mutants, and that cVA responses can be restored to dATP8B mutants by misexpressing a wild-type dATp8B rescuing transgene, by expressing a vertebrate P4-type ATPase member in the pheromone-sensing neurons or by overexpresseding Or 67d receptor subunits. Expand
The sensory neurone membrane protein SNMP1 contributes to the sensitivity of a pheromone detection system
TLDR
Reconstitution experiments demonstrate that the presence of SNMP1 significantly increases the HR13‐based responsiveness of cells to Z11‐16:Ald, suggesting thatSNMP1 also contributes to the response of the antennal neurones and thus to the remarkable sensitivity of the pheromone detection system. Expand
A Drosophila Protein Family Implicated in Pheromone Perception Is Related to Tay-Sachs GM2-Activator Protein*
TLDR
It is proposed that CheB proteins interact directly with lipid-like Drosophila pheromones and modulate their detection by the gustatory signal transduction machinery, and as loss of GM2-AP in Tay-Sachs disease prevents degradation ofGM2 gangliosides and results in neurodegeneration, the function of CheBs in phersomone response may involve biochemical mechanisms critical for lipid metabolism in human neurons. Expand
Requirement for Drosophila SNMP1 for Rapid Activation and Termination of Pheromone-Induced Activity
TLDR
It is found the snmp11 mutation did not abolish cVA responsiveness or cause high spontaneous activity, and the profound impairment in signal inactivation accounted for the previously reported “spontaneous activity,” which represented continuous activation following transient exposure to environmental cVA. Expand
Molecular elements of pheromone detection in the female moth, Heliothis virescens
TLDR
The data indicate that on the antenna of females, sensory neurons in a subset of sensilla trichodea are equipped with molecular elements, which render them responsive to pheromones, which point to congruent mechanisms for phersomone detection in the two sexes. Expand
Essential role for SNMP1 in detection of sex pheromones in Helicoverpa armigera.
TLDR
It is indicated that HarmSNMP1 has an important role in the detection of long-chain sex pheromones, but is not essential for detecting shorter chain sex peromone in vivo. Expand
The expression patterns of SNMP1 and SNMP2 underline distinct functions of two CD36-related proteins in the olfactory system of the tobacco budworm Heliothis virescens
TLDR
Findings indicate a potential function of SNMP2 in pheromone- as well as general odorant-responsive sensilla and a role fundamentally different from SNMP1. Expand
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