An essential role for RIG-I in toll-like receptor-stimulated phagocytosis.

  title={An essential role for RIG-I in toll-like receptor-stimulated phagocytosis.},
  author={Ling Kong and Lei Sun and Hongxin Zhang and Jingjing Liu and Ye Liu and Linhua Qin and Guojun Shi and J Hu and Ajing Xu and Yue-ping Sun and Dangsheng Li and Yu-fang Shi and Jing-Wu Zang and Jiang Yi Zhu and Zhu Chen and Zhugang Wang and B Ge},
  journal={Cell host & microbe},
  volume={6 2},
Retinoic acid-inducible gene-I (RIG-I) plays an important role in antiviral response by recognizing double-stranded RNA. Here we demonstrate an unanticipated role of RIG-I in Toll-like receptor (TLR)-stimulated phagocytosis. Stimulation with lipopolysaccharide (LPS), a ligand of TLR4, induced the expression of RIG-I in macrophages. Depletion of RIG-I by RNAi or gene targeting inhibited the LPS-induced phagocytosis of bacteria. Cellular processes involved in phagocytosis, such as small GTPase… CONTINUE READING


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