An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.

@article{Beg1996AnER,
  title={An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.},
  author={Amer A. Beg and David Baltimore},
  journal={Science},
  year={1996},
  volume={274 5288},
  pages={
          782-4
        }
}
Studies on mice deficient in nuclear factor kappa B (NF-kappaB) subunits have shown that this transcription factor is important for lymphocyte responses to antigens and cytokine-inducible gene expression. In particular, the RelA (p65) subunit is required for induction of tumor necrosis factor-alpha (TNF-alpha)-dependent genes. Treatment of RelA-deficient (RelA-/-) mouse fibroblasts and macrophages with TNF-alpha resulted in a significant reduction in viability, whereas RelA+/+ cells were… CONTINUE READING

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