An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.

@article{Pyatt1999AnER,
  title={An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.},
  author={David W. Pyatt and Wayne S. Stillman and Yanzhu Yang and Sherilyn A Gross and Jia Hua Zheng and Richard D. Irons},
  journal={Blood},
  year={1999},
  volume={93 10},
  pages={
          3302-8
        }
}
The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and… CONTINUE READING
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