An essential role for DNA adenine methylation in bacterial virulence.

@article{Heithoff1999AnER,
  title={An essential role for DNA adenine methylation in bacterial virulence.},
  author={Douglas M Heithoff and Robert L. Sinsheimer and David A. Low and Michael J. Mahan},
  journal={Science},
  year={1999},
  volume={284 5416},
  pages={967-70}
}
Salmonella typhimurium lacking DNA adenine methylase (Dam) were fully proficient in colonization of mucosal sites but showed severe defects in colonization of deeper tissue sites. These Dam- mutants were totally avirulent and were effective as live vaccines against murine typhoid fever. Dam regulated the expression of at least 20 genes known to be induced during infection; a subset of these genes are among those activated by the PhoP global virulence regulator. PhoP, in turn, affected Dam… CONTINUE READING
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