An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D.

@article{Jansen2007AnEO,
  title={An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D.},
  author={Silvia Jansen and Nico 3 Callewaert and Isabelle Dewerte and Maria J. Andries and Hugo Ceulemans and Mathieu Bollen},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 15},
  pages={11084-91}
}
Autotaxin/NPP2, a secreted lysophospholipase-D, promotes cell proliferation, survival, and motility by generating the signaling molecule lysophosphatidic acid. Here we show that ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2) is N-glycosylated on Asn-53, Asn-410, and Asn-524. Mutagenesis and deglycosylation experiments revealed that only the glycosylation of Asn-524 is essential for the expression of the catalytic and motility-stimulating activities of NPP2. The N-glycan on Asn-524… CONTINUE READING

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