An essential function for MKP5 in the formation of oxidized low density lipid-induced foam cells.

@article{Luo2012AnEF,
  title={An essential function for MKP5 in the formation of oxidized low density lipid-induced foam cells.},
  author={Li-jun Luo and Feng Liu and Xing-yu Wang and Tian-Yun Dai and Ya-lei Dai and Chen Dong and B Ge},
  journal={Cellular signalling},
  year={2012},
  volume={24 10},
  pages={1889-98}
}
The uptake of oxidized low density lipoprotein (ox-LDL) by macrophages usually leads to the formation of lipid-laden macrophages known as "foam cells," and this process plays an important role in the development of atherosclerosis. Ox-LDL activates mitogen-activated protein kinase (MAP) kinases and nuclear factor (NF)-κB, and activations of p38 and NF-κB are important for the formation of foam cells. MAP kinase phosphatase (MKP) 5 is a member of the dual specificity phosphatases (DUSPs) family… CONTINUE READING