An essential developmental checkpoint for production of the T cell lineage.

@article{Ikawa2010AnED,
  title={An essential developmental checkpoint for production of the T cell lineage.},
  author={Tomokatsu Ikawa and Satoshi Hirose and Kyoko Masuda and Kiyokazu Kakugawa and Rumi Satoh and Asako Shibano-Satoh and Ryo Kominami and Yoshimoto Katsura and Hiroshi Kawamoto},
  journal={Science},
  year={2010},
  volume={329 5987},
  pages={93-6}
}
In early T cell development, progenitors retaining the potential to generate myeloid and natural killer lineages are eventually determined to a specific T cell lineage. The molecular mechanisms that drive this determination step remain unclarified. We show that, when murine hematopoietic progenitors were cultured on immobilized Notch ligand DLL4 protein in the presence of a cocktail of cytokines including interleukin-7, progenitors developing toward T cells were arrested and the arrested cells… CONTINUE READING
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