An essential checkpoint for TLR9 signaling is release from 1 Unc93b1 in endosomes

@inproceedings{Majer2018AnEC,
  title={An essential checkpoint for TLR9 signaling is release from 1 Unc93b1 in endosomes},
  author={Olivia Majer and Brian M. Woo and Bo Liu and Erik Van Dis and Gregory M Barton},
  year={2018}
}
Nucleic acid-sensing Toll-like receptors (TLRs) are subject to complex regulation to facilitate recognition of microbial DNA and RNA while limiting recognition of self-nucleic acids1. Failure to properly regulate nucleic acid-sensing TLRs can lead to autoimmune and autoinflammatory disease2-6. Intracellular localization of these receptors is thought to be critical for self vs. non-self discrimination7, yet the molecular mechanisms that reinforce compartmentalized activation of intracellular… CONTINUE READING
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