1Cell and Molecular Biology Graduate Program, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. 2GlaxoSmithKline, King of Prussia, Pennsylvania, USA. 3The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. 4Safety Assessment, AstraZeneca Pharmaceuticals LP, Wilmington, Delaware, USA. 5School of Molecular and Microbial Biosciences, University of Sydney, New South Wales, Sydney, Australia. 6Department of Pharmacology, Rutgers University, Piscataway, New Jersey, USA.