An erythrocyte transketolase isoenzyme pattern associated with the Wernicke-Korsakoff syndrome.

@article{Nixon1984AnET,
  title={An erythrocyte transketolase isoenzyme pattern associated with the Wernicke-Korsakoff syndrome.},
  author={Peter F. Nixon and Maria Kaczmarek and Jillian R Tate and Robert A. Kerr and Joanne Price},
  journal={European journal of clinical investigation},
  year={1984},
  volume={14 4},
  pages={278-81}
}
Two techniques were used to seek variants of human erythrocyte transketolase and to test for any association of the Wernicke-Korsakoff syndrome, a thiamin-deficiency disease, with a particular variant of this thiamin-dependent enzyme. Apparent Km values for the cofactor thiamin diphosphate were similar for patients and controls. However, isoelectric focussing separated erythrocyte transketolase into different isoenzymes characterized by pI values in the range 6.6-9.2. Six distinct patterns of… CONTINUE READING

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