An error-prone T7 RNA polymerase mutant generated by directed evolution.

Abstract

Viruses replicate their genomes at exceptionally high mutation rates. Their offspring evolve rapidly and therefore, are able to evade common immunological and chemical antiviral agents. In parallel, virus genomes cannot tolerate a further increase in mutation rate: Experimental evidence exists that even few additional mutations are sufficient for the… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.