An ergosterol peroxide, a natural product that selectively enhances the inhibitory effect of linoleic acid on DNA polymerase beta.

@article{Mizushina1998AnEP,
  title={An ergosterol peroxide, a natural product that selectively enhances the inhibitory effect of linoleic acid on DNA polymerase beta.},
  author={Yoshiyuki Mizushina and Ichiro Watanabe and Humika Togashi and L Hanashima and Masaharu Takemura and Keisuke Ohta and Fumio Sugawara and Hiroyuki Koshino and Yasuaki Esumi and Jun Uzawa and Akio Matsukage and Shonen Yoshida and Kengo Sakaguchi},
  journal={Biological & pharmaceutical bulletin},
  year={1998},
  volume={21 5},
  pages={444-8}
}
As described previously (Mizushina Y., Tanaka N., Yagi H., Kurosawa T., Onoue M., Seto H., Horie T., Aoyagi N., Yamaoka M., Matsukage A., Yoshida S., and Sakaguchi K., Biochim. Biophys. Acta, 1308, 256-262, 1996), linoleic acid (LA) inhibits the activities of mammalian DNA polymerases. We found a natural product from a basidiomycete, Ganoderma lucidum, that enhances this effect of LA in a special manner. The structure was identified to be an ergosterol peroxide, 5,8-epidioxy-5alpha,8alpha… CONTINUE READING