An epitope of the Semliki Forest virus fusion protein exposed during virus-membrane fusion.

@article{Ahn1999AnEO,
  title={An epitope of the Semliki Forest virus fusion protein exposed during virus-membrane fusion.},
  author={Anna Ahn and M R Klimjack and Prodyot K. Chatterjee and Margaret Kielian},
  journal={Journal of virology},
  year={1999},
  volume={73 12},
  pages={10029-39}
}
Semliki Forest virus (SFV) is an enveloped alphavirus that infects cells via a membrane fusion reaction triggered by acidic pH in the endocytic pathway. Fusion is mediated by the spike protein E1 subunit, an integral membrane protein that contains the viral fusion peptide and forms a stable homotrimer during fusion. We have characterized four monoclonal antibodies (MAbs) specific for the acid conformation of E1. These MAbs did not inhibit fusion, suggesting that they bind to an E1 region… CONTINUE READING
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