An epigenome-wide association study of total serum IgE in Hispanic children.

  title={An epigenome-wide association study of total serum IgE in Hispanic children.},
  author={Wei Chen and Ting Wang and Maria Pino-Yanes and Erick Forno and Liming Liang and Qi Yan and Donglei Hu and Daniel E. Weeks and Andrea A. Baccarelli and Edna Acosta-P{\'e}rez and Celeste Eng and Yueh-Ying Han and Nadia Boutaoui and Catherine Laprise and G A Davies and Julian M. Hopkin and Miriam F Moffatt and William O. C. M. Cookson and Glorisa J. Canino and Esteban Gonz{\`a}lez Burchard and Juan C Celed{\'o}n},
  journal={The Journal of allergy and clinical immunology},
  volume={140 2},
BACKGROUND Total IgE is a therapeutic target in patients with allergic diseases. DNA methylation in white blood cells (WBCs) was associated with total IgE levels in an epigenome-wide association study of white subjects. Whether DNA methylation of eosinophils explains these findings is insufficiently understood. METHODS We tested for association between genome-wide DNA methylation in WBCs and total IgE levels in 2 studies of Hispanic children: the Puerto Rico Genetics of Asthma and Lifestyle… CONTINUE READING

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