An epigenetic switch governing daughter cell separation in Bacillus subtilis.

@article{Chai2010AnES,
  title={An epigenetic switch governing daughter cell separation in Bacillus subtilis.},
  author={Yunrong Chai and Thomas Norman and Roberto Kolter and Richard Losick},
  journal={Genes & development},
  year={2010},
  volume={24 8},
  pages={
          754-65
        }
}
Growing cells of Bacillus subtilis are a bistable mixture of individual motile cells in which genes for daughter cell separation and motility are ON, and chains of sessile cells in which these genes are OFF. How this ON/OFF switch is controlled has been mysterious. Here we report that a complex of the SinR and SlrR proteins binds to and represses genes involved in cell separation and motility. We also report that SinR and SlrR constitute a double-negative feedback loop in which SinR represses… CONTINUE READING
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