An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state.

@article{Pedersen2013AnEM,
  title={An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state.},
  author={Mikael Egebjerg Pedersen and Goda Snieckute and Konstantinos Kagias and Camilla Nehammer and Hinke A. B. Multhaupt and John Robert Couchman and Roger Pocock},
  journal={Science},
  year={2013},
  volume={341 6152},
  pages={1404-8}
}
An appropriate balance in glycosylation of proteoglycans is crucial for their ability to regulate animal development. Here, we report that the Caenorhabditis elegans microRNA mir-79, an ortholog of mammalian miR-9, controls sugar-chain homeostasis by targeting two proteins in the proteoglycan biosynthetic pathway: a chondroitin synthase (SQV-5; squashed vulva-5) and a uridine 5'-diphosphate-sugar transporter (SQV-7). Loss of mir-79 causes neurodevelopmental defects through SQV-5 and SQV-7… CONTINUE READING
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