An epidemiologic study of trends in prevalence of rheumatoid factor seropositivity in Pima Indians: evidence of a decline due to both secular and birth-cohort influences.

@article{Enzer2002AnES,
  title={An epidemiologic study of trends in prevalence of rheumatoid factor seropositivity in Pima Indians: evidence of a decline due to both secular and birth-cohort influences.},
  author={Ian Enzer and G. Dunn and Lennart Jacobsson and Peter H. Bennett and William C. Knowler and Alan Jonathan Silman},
  journal={Arthritis and rheumatism},
  year={2002},
  volume={46 7},
  pages={1729-34}
}
OBJECTIVE Previous population studies have suggested that both rheumatoid factor (RF) production and rheumatoid arthritis (RA) may be declining in occurrence, and both secular and birth-cohort influences have been implicated. Since Pima Indians have a very high incidence of RA and also have shown recent evidence of a decline in RA, this study evaluated the relative contributions of age, secular, and birth-cohort influences on RF seropositivity in the Pima Indian population. METHODS RF data… CONTINUE READING

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