An epidemic Burkholderia cepacia complex strain identified in soil

@article{Lipuma2002AnEB,
  title={An epidemic Burkholderia cepacia complex strain identified in soil},
  author={John J. Lipuma and Theodore Spilker and Tom Coenye and Carlos Gonzalez},
  journal={The Lancet},
  year={2002},
  volume={359},
  pages={2002-2003}
}
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193 Citations
Highly Influential Citations
10
Background Citations
90
Methods Citations
19
Results Citations
5

193 Citations

The multifarious, multireplicon Burkholderia cepacia complex
TLDR
The unique characteristics of the Bcc are highlighted, focusing on the factors that determine virulence, and some members can also degrade natural and man-made pollutants.
Factors Influencing Acquisition of Burkholderia cepacia Complex Organisms in Patients with Cystic Fibrosis
TLDR
This study demonstrates that despite strict cohort segregation, new cases of unrelated B. cepacia complex infection continue to occur and supports an environmental origin of infection and suggest that climate conditions may be associated with the acquisition of B. Cepaciacomplex infections.
Burkholderia cepacia Complex: Emerging Multihost Pathogens Equipped with a Wide Range of Virulence Factors and Determinants
TLDR
These and other traits of Bcc bacteria are reviewed, as well as some of the strategies used to identify and validate the virulence factors and determinants used by these bacteria, to help design novel therapeutic strategies to fight the infections caused by these emergent multidrug resistant human pathogens.
Exceptionally High Representation of Burkholderia cepacia among B. cepacia Complex Isolates Recovered from the Major Portuguese Cystic Fibrosis Center
ABSTRACT Burkholderia cepacia, a species found infrequently in cystic fibrosis (CF), was isolated from 85% of patients infected with bacteria of the B. cepacia complex that visited the major…
A Decade of Burkholderia cenocepacia Virulence Determinant Research
TLDR
A common theme emerging from these studies is that B. cenocepacia establishes chronic infections in immunocompromised patients, which depend more on determinants mediating host niche adaptation than those involved directly in host cells and tissue damage.
Molecular epidemiology of Burkholderia species.
TLDR
Although most species in the genus Burkholderia are not pathogenic for healthy persons, a few are capable of causing severe, life threatening infection and interest in these species has increased recently owing to their potential for use as agents of bioterrorism.
Environmental Burkholderia cepacia Complex Isolates from Human Infections
TLDR
This finding links the natural environment with the emergence of many Bcc infections.
The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients
TLDR
Pseudogenes in virulence determinants suggest that the pathogenic response of J2315 may have been recently selected to promote persistence in the CF lung, and contains evidence that its unique and highly adapted genetic content has played a significant role in its success as an epidemic CF pathogen.
The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients
TLDR
The J2315 genome contains evidence that its unique and highly adapted genetic content has played a significant role in its success as an epidemic CF pathogen, and Pseudogenes in virulence determinants suggest that the pathogenic response of J 2315 may have been recently selected to promote persistence in the CF lung.
Update on the Burkholderia cepacia complex
  • J. Lipuma
  • Biology, Medicine
    Current opinion in pulmonary medicine
  • 2005
TLDR
Advances in understanding of Burkholderia cepacia complex infection in cystic fibrosis serve as a critical foundation for further efforts that ultimately will enable better infection control and the development of novel therapeutics to treat Burk holderia cEPacia complex infections in persons with cystic Fibrosis.
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References

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TLDR
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TLDR
The capability of this bacterial complex to cause disease in plants and humans, as well as to control plant diseases, affords a rare opportunity to explore traits that may function in all three environments.