An epidemic, toxin gene-variant strain of Clostridium difficile.

  title={An epidemic, toxin gene-variant strain of Clostridium difficile.},
  author={L. Clifford McDonald and George E. Killgore and Angela D. Thompson and Robert C. Jr Owens and Sophia V. Kazakova and Susan P. Sambol and Stuart Johnson and Dale N. Gerding},
  journal={The New England journal of medicine},
  volume={353 23},
BACKGROUND Recent reports suggest that the rate and severity of Clostridium difficile-associated disease in the United States are increasing and that the increase may be associated with the emergence of a new strain of C. difficile with increased virulence, resistance, or both. METHODS A total of 187 C. difficile isolates were collected from eight health care facilities in six states (Georgia, Illinois, Maine, New Jersey, Oregon, and Pennsylvania) in which outbreaks of C. difficile-associated… 

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