An enzyme with a deep trefoil knot for the active-site architecture.

  title={An enzyme with a deep trefoil knot for the active-site architecture.},
  author={Osamu Nureki and Mikako Shirouzu and Kyoko Hashimoto and Ryuichiro Ishitani and Takaho Terada and Masatada Tamakoshi and Tairo Oshima and Masao Chijimatsu and Koji Takio and Dmitry G. Vassylyev and Takehiko Shibata and Yorinao Inoue and Seiki Kuramitsu and Shigeyuki Yokoyama},
  journal={Acta crystallographica. Section D, Biological crystallography},
  volume={58 Pt 7},
Knots in polypeptide chains have been found in very few proteins. Only two proteins are considered to have a shallow 'trefoil' knot, which tucks a few residues at one end of the chain through a loop exposed on the protein surface. Recently, another protein was found by a mathematical algorithm to have a deep 'figure-of-eight' knot which had not been visually identified. In the present study, the crystal structure of a hypothetical RNA 2'-O-ribose methyltransferase from Thermus thermophilus… CONTINUE READING

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