An enzyme-sensitive PEG hydrogel based on aggrecan catabolism for cartilage tissue engineering.

@article{Skaalure2015AnEP,
  title={An enzyme-sensitive PEG hydrogel based on aggrecan catabolism for cartilage tissue engineering.},
  author={Stacey C. Skaalure and Stanley Chu and Stephanie J Bryant},
  journal={Advanced healthcare materials},
  year={2015},
  volume={4 3},
  pages={420-31}
}
A new cartilage-specific degradable hydrogel based on photoclickable thiol-ene poly(ethylene glycol) (PEG) hydrogels is presented. The hydrogel crosslinks are composed of the peptide, CRDTEGE-ARGSVIDRC, derived from the aggrecanase-cleavable site in aggrecan. This new hydrogel is evaluated for use in cartilage tissue engineering by encapsulating bovine chondrocytes from different cell sources (skeletally immature (juvenile) and mature (adult) donors and adult cells stimulated with… CONTINUE READING

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