An enzyme-linked immunosorbent assay for therapeutic drug monitoring of infliximab.

@article{Ternant2006AnEI,
  title={An enzyme-linked immunosorbent assay for therapeutic drug monitoring of infliximab.},
  author={David Ternant and Denis Mulleman and Danielle Degenne and St{\'e}phanie Willot and Jean Claude Guillaumin and Herv{\'e} Watier and Philippe Goupille and Gilles Paintaud},
  journal={Therapeutic drug monitoring},
  year={2006},
  volume={28 2},
  pages={
          169-74
        }
}
An enzyme-linked immunosorbent assay (ELISA) measuring serum infliximab concentrations in treated patients was developed. Microtiter plates were sensitized with tumor necrosis factor alpha (TNF-alpha) and saturated with phosphate-buffered saline (PBS) containing 1% bovine serum albumin (BSA). Samples diluted 1:100 in PBS-1% BSA were added and bound infliximab was detected using peroxidase-conjugated goat anti-human immunoglobulin G specific for Fc fragment (HRP-anti hIgG). Reading was performed… CONTINUE READING

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