An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

@article{Moncada1976AnEI,
  title={An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation},
  author={S. Moncada and R. Gryglewski and S. Bunting and J. Vane},
  journal={Nature},
  year={1976},
  volume={263},
  pages={663-665}
}
Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that inhibited human platelet aggregation. PGX was 30 times more potent in this respect than prostaglandin E1. PGX contracted some gastrointestinal smooth muscle and relaxed certain isolated blood vessels. Prostaglandin endoperoxides cause platelet aggregation possibly through the generation by platelets of thromboxane A2. Generation of PGX by vessel walls could be the… Expand
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References

SHOWING 1-10 OF 20 REFERENCES
Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiency.
Prostaglandin D2 inhibits the aggregation of human platelets.
Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis.
  • M. Hámberg, B. Samuelsson
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1973
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.
  • M. Hámberg, B. Samuelsson
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1974
Effects of Platelet Transfusions: Plug Formation and Maintenance of Vascular Integrity
  • A. Roy, I. Djerassi
  • Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1972
Isolation and properties of intermediates in prostaglandin biosynthesis.
...
1
2
...