An enzymatic mechanism for the antithrombotic and antihemostatic actions of aspirin.

Abstract

Aspirin-type drugs may inhibit irreversible clumping of human blood platelets by blocking the enzymatic conversion of arachidonic acid to a hitherto undiscovered factor, labile aggregation-stimulating substance, which triggers aggregation and to prostaglandin E(2), which sensitizes the platelets to its aggregatory effects.

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@article{Willis1974AnEM, title={An enzymatic mechanism for the antithrombotic and antihemostatic actions of aspirin.}, author={Anthony L. Willis}, journal={Science}, year={1974}, volume={183 4122}, pages={325-7} }