An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway

@article{Shin2005AnEC,
  title={An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway},
  author={Hye-Won Shin and Mitsuko Hayashi and Savvas Christoforidis and Sandra Lacas‐Gervais and Sebastian Hoepfner and Markus R. Wenk and Jan Modregger and Sandrine Uttenweiler-Joseph and Matthias Wilm and Arne M Nystuen and Wayne N. Frankel and Michele Solimena and Pietro De Camilli and Marino Zerial},
  journal={The Journal of Cell Biology},
  year={2005},
  volume={170},
  pages={607 - 618}
}
Generation and turnover of phosphoinositides (PIs) must be coordinated in a spatial- and temporal-restricted manner. The small GTPase Rab5 interacts with two PI 3-kinases, Vps34 and PI3Kβ, suggesting that it regulates the production of 3-PIs at various stages of the early endocytic pathway. Here, we discovered that Rab5 also interacts directly with PI 5- and PI 4-phosphatases and stimulates their activity. Rab5 regulates the production of phosphatidylinositol 3-phosphate (PtdIns[3]P) through a… 

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