An envelope domain III-based chimeric antigen produced in Pichia pastoris elicits neutralizing antibodies against all four dengue virus serotypes.

@article{Etemad2008AnED,
  title={An envelope domain III-based chimeric antigen produced in Pichia pastoris elicits neutralizing antibodies against all four dengue virus serotypes.},
  author={Behzad Etemad and Gaurav Batra and Rajendra Raut and Satinder Dahiya and Saima Khanam and Sathyamangalam Swaminathan and Navin C. Khanna},
  journal={The American journal of tropical medicine and hygiene},
  year={2008},
  volume={79 3},
  pages={353-63}
}
There is currently no vaccine to prevent dengue (DEN) virus infection, which is caused by any one of four closely related serotypes, DEN-1, DEN-2, DEN-3, or DEN-4. A DEN vaccine must be tetravalent, because immunity to a single serotype does not offer cross-protection against the other serotypes. We have developed a novel tetravalent chimeric protein by fusing the receptor-binding envelope domain III (EDIII) of the four DEN virus serotypes. This protein was expressed in the yeast, Pichia… CONTINUE READING

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There is currently no vaccine to prevent dengue ( DEN ) virus infection , which is caused by any one of four closely related serotypes , DEN-1 , DEN-2 , DEN-3 , or DEN-4 .
There is currently no vaccine to prevent dengue ( DEN ) virus infection , which is caused by any one of four closely related serotypes , DEN-1 , DEN-2 , DEN-3 , or DEN-4 .
There is currently no vaccine to prevent dengue ( DEN ) virus infection , which is caused by any one of four closely related serotypes , DEN-1 , DEN-2 , DEN-3 , or DEN-4 .
There is currently no vaccine to prevent dengue ( DEN ) virus infection , which is caused by any one of four closely related serotypes , DEN-1 , DEN-2 , DEN-3 , or DEN-4 .
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