An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity.

@article{BenShabat1998AnEE,
  title={An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity.},
  author={S. Ben-Shabat and E. Fride and T. Sheskin and T. Tamiri and M. Rhee and Z. Vogel and T. Bisogno and L. De Petrocellis and V. Di Marzo and R. Mechoulam},
  journal={European journal of pharmacology},
  year={1998},
  volume={353 1},
  pages={
          23-31
        }
}
2-Arachidonoyl-glycerol (2-Ara-GI) has been isolated from various tissues and identified as an endogenous ligand for both cannabinoid receptors, CB1 and CB2. Here we report that in spleen, as in brain and gut, 2-Ara-GI is accompanied by several 2-acyl-glycerol esters, two major ones being 2-linoleoyl-glycerol (2-Lino-Gl) and 2-palmitoyl-glycerol (2-Palm-Gl). These two esters do not bind to the cannabinoid receptors, nor do they inhibit adenylyl cyclase via either CB1 or CB2; however, they… Expand
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