An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity.

@article{BenShabat1998AnEE,
  title={An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity.},
  author={Shimon Ben-Shabat and Ester Fride and Tzviel Sheskin and Tsippy Tamiri and Man Hee Rhee and Zvi Vogel and Tiziana Bisogno and Luciano De Petrocellis and Vincenzo Di Marzo and Raphael Mechoulam},
  journal={European journal of pharmacology},
  year={1998},
  volume={353 1},
  pages={23-31}
}
2-Arachidonoyl-glycerol (2-Ara-GI) has been isolated from various tissues and identified as an endogenous ligand for both cannabinoid receptors, CB1 and CB2. Here we report that in spleen, as in brain and gut, 2-Ara-GI is accompanied by several 2-acyl-glycerol esters, two major ones being 2-linoleoyl-glycerol (2-Lino-Gl) and 2-palmitoyl-glycerol (2-Palm-Gl). These two esters do not bind to the cannabinoid receptors, nor do they inhibit adenylyl cyclase via either CB1 or CB2; however, they… CONTINUE READING