An ensemble view of thrombin allostery

  title={An ensemble view of thrombin allostery},
  author={Bernhard C. Lechtenberg and Stefan M. V. Freund and James A Huntington},
  booktitle={Biological chemistry},
Abstract Thrombin is the central protease of the coagulation cascade. Its activity is tightly regulated to ensure rapid blood clotting while preventing uncontrolled thrombosis. Thrombin interacts with multiple substrates and cofactors and is critically involved in both pro- and anticoagulant pathways of the coagulation network. Its allosteric regulation, especially by the monovalent cation Na+, has been the focus of research for more than 30 years. It is believed that thrombin can adopt an… 

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  • J. Huntington
  • Biology
    Journal of thrombosis and haemostasis : JTH
  • 2005
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