An ensemble strategy that significantly improves de novo assembly of microbial genomes from metagenomic next-generation sequencing data

@inproceedings{Deng2015AnES,
  title={An ensemble strategy that significantly improves de novo assembly of microbial genomes from metagenomic next-generation sequencing data},
  author={Xutao Deng and Samia N. Naccache and Terry Fei Fan Ng and Scot Federman and Linlin Li and Charles Y Chiu and Eric L Delwart},
  booktitle={Nucleic acids research},
  year={2015}
}
Next-generation sequencing (NGS) approaches rapidly produce millions to billions of short reads, which allow pathogen detection and discovery in human clinical, animal and environmental samples. A major limitation of sequence homology-based identification for highly divergent microorganisms is the short length of reads generated by most highly parallel sequencing technologies. Short reads require a high level of sequence similarities to annotated genes to confidently predict gene function or… CONTINUE READING
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