An enhancer peptide for membrane-disrupting antimicrobial peptides

@inproceedings{Ueno2009AnEP,
  title={An enhancer peptide for membrane-disrupting antimicrobial peptides},
  author={Satoshi Ueno and Kohtaro Kusaka and Yasushi Tamada and Hong Zhang and Masaomi Minaba and Yusuke Kato},
  booktitle={BMC Microbiology},
  year={2009}
}
NP4P is a synthetic peptide derived from a natural, non-antimicrobial peptide fragment (pro-region of nematode cecropin P4) by substitution of all acidic amino acid residues with amides (i.e., Glu → Gln, and Asp → Asn). In the presence of NP4P, some membrane-disrupting antimicrobial peptides (ASABF-α, polymyxin B, and nisin) killed microbes at lower concentration (e.g., 10 times lower minimum bactericidal concentration for ASABF-α against Staphylococcus aureus), whereas NP4P itself was not… CONTINUE READING
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