An engineered protein tag for multiprotein labeling in living cells.

  title={An engineered protein tag for multiprotein labeling in living cells.},
  author={Arnaud Gautier and Alexandre Juillerat and Christian Heinis and Ivan R Corr{\^e}a and Maik Kindermann and Florent Beaufils and Kai Johnsson},
  journal={Chemistry & biology},
  volume={15 2},
The visualization of complex cellular processes involving multiple proteins requires the use of spectroscopically distinguishable fluorescent reporters. We have previously introduced the SNAP-tag as a general tool for the specific labeling of SNAP-tag fusion proteins in living cells. The SNAP-tag is derived from the human DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT) and can be covalently labeled in living cells using O6-benzylguanine derivatives bearing a chemical probe. Here… CONTINUE READING
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