An energy model that predicts the correct folding of both the tRNA and the 5S RNA molecules

@article{Papanicolaou1984AnEM,
  title={An energy model that predicts the correct folding of both the tRNA and the 5S RNA molecules},
  author={Catherine Papanicolaou and Manolo Gouy and Jacques Ninio},
  journal={Nucleic acids research},
  year={1984},
  volume={12 1 Pt 1},
  pages={31-44}
}
A new set of energy values to predict the secondary structures in RNA molecules has been derived through a multiple-step refinement procedure. It achieves more than 80% success in predicting the cloverleaf pattern in tRNA (200 sequences tested) and more than 60% success in predicting the consensus folding of 5S RNA (100 sequences). Improvements in our initial program for predicting secondary structures, based on the principle of the "incompatibility islets" made possible the work on 5S RNA. The… CONTINUE READING

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