An endothelium‐dependent contraction in canine mesenteric artery caused by caffeine

@article{Jino1994AnEC,
  title={An endothelium‐dependent contraction in canine mesenteric artery caused by caffeine},
  author={Hiroshi Jino and Hachiro Usui and Shinji Temma and Hiroaki Shirahase and Kazuyoshi Kurahashi},
  journal={British Journal of Pharmacology},
  year={1994},
  volume={111}
}
1 We examined whether or not caffeine caused an endothelium‐dependent contraction (EDC) in canine mesenteric artery and whether the endothelium‐dependent contracting factors (EDCF) were arachidonic acid metabolites. 2 Caffeine (1, 3 and 10 mm) caused a transient contraction in endothelium‐intact arterial strips. Removal of the endothelium significantly attenuated the caffeine (1 and 3 mm)‐induced contraction. 3 Caffeine (1 mm)‐induced EDC was not affected by quinacrine and manoalide… 
Tetrandrine potentiates caffeine-induced contraction but inhibits phenylephrine-induced contraction in perfused rat mesenteric artery
  • C. Kwan
  • Biology, Chemistry
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2002
TLDR
It is proposed that TET elicits differential effects on PE- and caffeine-induced responses in perfused rat mesenteric arterial bed and is likely to be due to its partial inhibition of the sarcoplasmic reticulum Ca2+-ATPase pump.
Unaltered caffeine-induced relaxation in the aorta of stroke-prone spontaneously hypertensive rats (SHRSP).
TLDR
The results suggest that the relaxation induced by caffeine in these preparations is brought about by its direct effect on smooth muscle and that the response of the smooth muscle to caffeine, including cAMP production, is not altered in preparations from SHRSP compared with those from WKY.
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It is concluded that TXA2 is produced in the endothelial cells and may be involved in maintaining the resting tone and contractile response to AA in the canine cerebral artery.
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TLDR
It is demonstrated that relaxation of isolated preparations of rabbit thoracic aorta and other blood vessels by ACh requires the presence of endothelial cells, and that ACh, acting on muscarinic receptors of these cells, stimulates release of a substance(s) that causes relaxation of the vascular smooth muscle.
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