An endothelial laminin isoform, laminin 8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis.

@article{Wondimu2004AnEL,
  title={An endothelial laminin isoform, laminin 8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis.},
  author={Zenebech Wondimu and Tarekegn Geberhiwot and Sulev Ingerpuu and Erkki Juronen and Xun Xie and Lennart Lindbom and Masayuki Doi and Jarkko Kortesmaa and Jill Thyboll and K. Tryggvason and Bengt Fadeel and Manuel Elkin Patarroyo},
  journal={Blood},
  year={2004},
  volume={104 6},
  pages={1859-66}
}
During extravasation, neutrophils migrate through the perivascular basement membrane (BM), a specialized extracellular matrix rich in laminins. Laminins 8 (LN-8) (alpha4beta1gamma1) and 10 (LN-10) (alpha5beta1gamma1) are major components of the endothelial BM, but expression, recognition, and use of these laminin isoforms by neutrophils are poorly understood. In the present study, we provide evidence, using a panel of novel monoclonal antibodies against human laminin alpha4 (LNalpha4) chain… CONTINUE READING

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