An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II.

@article{Hajjar1994AnEC,
  title={An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II.},
  author={Katherine A Hajjar and Andrew T. Jacovina and J Anthony Chacko},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 33},
  pages={
          21191-7
        }
}
Sequencing of two internal peptides from the putative human endothelial cell tissue plasminogen activator (t-PA) receptor identified an analog of the calcium- and phospholipid-binding protein, annexin II (Ann-II). The polymerase chain reaction-derived, full-length cDNA revealed complete sequence identity with the heavy chain of Ann-II, and ligand-precipitated receptor protein immunoreacted specifically with a monoclonal antibody to Ann-II. Transfected 293 cells bound plasminogen (Kd = 114 nM… CONTINUE READING

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