An endoplasmic reticulum trafficking signal regulates surface expression of β4 subunit of a voltage- and Ca²⁺-activated K⁺ channel.

@article{Cox2014AnER,
  title={An endoplasmic reticulum trafficking signal regulates surface expression of β4 subunit of a voltage- and Ca²⁺-activated K⁺ channel.},
  author={Nancy Cox and Bigboy Toro and L F Pacheco-Otalora and Emilio Rafael Garrido-Sanabria and Masoud M Zarei},
  journal={Brain research},
  year={2014},
  volume={1553},
  pages={12-23}
}
Voltage-dependent and calcium-activated K⁺ (MaxiK, BK) channels are widely expressed in many tissues and organs where they play various physiological roles. Here we report discovery of a functional trafficking signal in MaxiK channel accessory β4 subunit that could regulate activity of MaxiK α subunit (hSlo) on the plasma membrane. We demonstrate that β4 is mostly retained within the cell and removal or mutation of β4 trafficking signal significantly enhances its surface expression in HEK293T… CONTINUE READING

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