An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites.


The emergence of artemisinin-resistant Plasmodium falciparum malaria in Southeast Asia has reinforced the urgent need to discover novel chemotherapeutic strategies to treat and control malaria. To address this problem, we prepared a set of dual-acting tetraoxane-based hybrid molecules designed to deliver a falcipain-2 (FP-2) inhibitor upon activation by… (More)
DOI: 10.1002/cmdc.201300202


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