An endometrial stromal sarcoma cell line with the JAZF1/PHF1 chimera.

  title={An endometrial stromal sarcoma cell line with the JAZF1/PHF1 chimera.},
  author={Ioannis Panagopoulos and Fredrik Mertens and Constance A. Griffin},
  journal={Cancer genetics and cytogenetics},
  volume={185 2},
Endometrial stromal sarcomas (ESS) are rare malignancies, accounting for less than 10% of uterine sarcomas. Apart from the chromosomal rearrangement t(7;17)(p15;q21), which leads to the JAZF1/SUZ12 chimera, cytogenetic studies have shown that the chromosome band 6p21 is often rearranged in ESS. The translocation partners involved in the 6p21 rearrangements differ among the tumors, but chromosome 7 is involved in most aberrations. A JAZF1/PHF1 fusion gene was recently found in two tumors showing… CONTINUE READING
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