An endoluminal sleeve induces substantial weight loss and normalizes glucose homeostasis in rats with diet-induced obesity.

@article{Aguirre2008AnES,
  title={An endoluminal sleeve induces substantial weight loss and normalizes glucose homeostasis in rats with diet-induced obesity.},
  author={Vincent P. Aguirre and Nicholas Stylopoulos and Ronit Grinbaum and Lee M. Kaplan},
  journal={Obesity},
  year={2008},
  volume={16 12},
  pages={2585-92}
}
To investigate the contributions of two surgical gut manipulations-exclusion of the proximal intestine from alimentary flow and exposure of the jejunum to partially digested nutrients-to body weight regulation and metabolism, we have developed a rat model of an investigational device, the endoluminal sleeve (ELS). The ELS is a 10 cm, nutrient-impermeable, flexible tube designed for endoluminal implantation. ELS devices were surgically implanted in the duodenal bulb of rats with diet-induced… CONTINUE READING
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