An endogenous factor induces heterogeneity of binding sites of selective muscarinic receptor antagonists in rat heart.

@article{Fryer1989AnEF,
  title={An endogenous factor induces heterogeneity of binding sites of selective muscarinic receptor antagonists in rat heart.},
  author={Andrew D Fryer and Esam E. El-Fakahany},
  journal={Membrane biochemistry},
  year={1989},
  volume={8 3},
  pages={127-32}
}
According to molecular biological and pharmacological criteria, rat heart membranes normally express only one muscarinic receptor subtype. The selective antagonists pirenzepine and AF-DX 116 bind to this receptor with a single affinity: low and high, respectively. We report here that an endogenous, intracellular factor alters the affinity of selective… CONTINUE READING