An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis.

@article{Quintana2010AnEA,
  title={An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis.},
  author={Francisco J. Quintana and Gopal Murugaiyan and Mauricio Franco Farez and Meike Mitsdoerffer and Ann-Marcia Tukpah and Evan J. Burns and Howard L. Weiner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 48},
  pages={20768-73}
}
The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) participates in the differentiation of FoxP3(+) T(reg), Tr1 cells, and IL-17-producing T cells (Th17). Most of our understanding on the role of AHR on the FoxP3(+) T(reg) compartment results from studies using the toxic synthetic chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin. Thus, the physiological relevance of AHR signaling on FoxP3(+) T(reg) in vivo is unclear. We studied mice that carry a GFP reporter in the endogenous… CONTINUE READING
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Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells

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