An endogenous adrenoceptor ligand potentiates excitatory synaptic transmission in cultured hippocampal neurons.

@article{Aubert2001AnEA,
  title={An endogenous adrenoceptor ligand potentiates excitatory synaptic transmission in cultured hippocampal neurons.},
  author={Muriel Aubert and Janique Guiramand and Ariane Croce and Gis{\`e}le Roch and A. Szafarczyk and Michel Vignes},
  journal={Cerebral cortex},
  year={2001},
  volume={11 9},
  pages={878-87}
}
Noradrenergic inputs modulate hippocampal function via distinct receptors. In hippocampal neuronal cultures, mRNA expression of adrenoceptor subtypes is maintained from 1 day in vitro (DIV) to 22 DIV. Noradrenaline dose-dependently stimulates phosphoinositide (PI) breakdown in both immature and mature cultures through the activation of alpha1 receptors. At 22 DIV, basal PI breakdown depends on excitatory synaptic activity since it is decreased by tetrodotoxin or glutamate receptor antagonists… CONTINUE READING