An endocannabinoid mechanism for stress-induced analgesia

@article{Hohmann2005AnEM,
  title={An endocannabinoid mechanism for stress-induced analgesia},
  author={A. Hohmann and R. L. Suplita and Nathan M. Bolton and M. H. Neely and D. Fegley and R. Mangieri and J. Krey and J. M. Walker and P. Holmes and J. Crystal and A. Duranti and A. Tontini and M. Mor and G. Tarzia and D. Piomelli},
  journal={Nature},
  year={2005},
  volume={435},
  pages={1108-1112}
}
Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid mechanisms. Here we show that an opioid-independent form of this phenomenon, termed stress-induced analgesia, is mediated by the release of endogenous marijuana-like (cannabinoid) compounds in the brain. Blockade of cannabinoid CB1 receptors in the periaqueductal grey matter of the midbrain prevents non-opioid stress-induced analgesia. In this region, stress elicits the rapid formation of two endogenous… Expand
649 Citations
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia
  • 72
The endocannabinoid system and pain.
  • 320
  • PDF
Endocannabinoid mechanisms of pain modulation
  • 189
Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia
  • 69
Stress‐induced analgesia in mice: evidence for interaction between endocannabinoids and cholecystokinin
  • 25
  • Highly Influenced
The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress.
  • 23
  • PDF
Targeting the cannabinoid system for pain relief?
  • Lih-Chu Chiou, S. Hu, Y. Ho
  • Medicine
  • Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists
  • 2013
  • 42
Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids
  • M. Hill, B. McEwen
  • Biology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2010
  • 192
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 36 REFERENCES
Modulation of anxiety through blockade of anandamide hydrolysis
  • 846
  • PDF
Pain modulation by release of the endogenous cannabinoid anandamide.
  • 467
  • PDF
The Many Possible Roles of Opioids and Related Peptides in Stress‐Induced Analgesia a
  • 75
  • PDF
Brain monoglyceride lipase participating in endocannabinoid inactivation
  • 1,156
  • PDF
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.
  • 997
  • PDF
...
1
2
3
4
...