An emerging understanding of the Janus face of the human microbiome: enhancement versus impairment of cancer therapy.

@article{VandeVoorde2014AnEU,
  title={An emerging understanding of the Janus face of the human microbiome: enhancement versus impairment of cancer therapy.},
  author={Johan Vande Voorde and Jan Balzarini and Sandra Liekens},
  journal={The Journal of antimicrobial chemotherapy},
  year={2014},
  volume={69 10},
  pages={
          2878-80
        }
}
Sir, Commensal bacteria have been shown to modulate myeloidderived cell functions in the tumour microenvironment that are crucial for an optimal response to immunotherapy or platinumbased chemotherapy. Also, the therapeutic efficacy of cyclophosphamide has been proven to be mediated by selected species of Gram-positive bacteria that stimulate a specific anticancer immune response. As a result, a decreased efficiency of cancer therapy was reported in germ-free or antibiotic-treated mice. These… 

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