An emerging role for neutrophil extracellular traps in noninfectious disease

@article{Jorch2017AnER,
  title={An emerging role for neutrophil extracellular traps in noninfectious disease},
  author={Selina K Jorch and Paul Kubes},
  journal={Nature Medicine},
  year={2017},
  volume={23},
  pages={279-287}
}
The production of neutrophil extracellular traps (NETs) is a process that enables neutrophils to help catch and kill bacteria. However, increasing evidence suggests that this process might also occur in noninfectious, sterile inflammation. In this Review, we describe the role of NETosis in autoimmunity, coagulation, acute injuries and cancer, and discuss NETs as potential therapeutic targets. Furthermore, we consider whether extracellular DNA is always detrimental in sterile inflammation and… 
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573 Citations
Highly Influential Citations
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573 Citations

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Citation Type

Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system
  • M. Honda, P. Kubes
  • Biology, Medicine
    Nature Reviews Gastroenterology & Hepatology
  • 2018
TLDR
The role of NETs in the liver and gastrointestinal system is focused on, outlining their protective and pathological effects and the potential importance of NET-related molecules, including cell-free DNA and hypercitrullinated histones, as biomarkers and targets for therapeutic intervention in gastrointestinal diseases is described.
Neutrophil Extracellular Traps in Autoimmune Diseases
TLDR
Neutrophil extracellular traps deliver multiple autoantigens to host immune system that induce autoimmune responses and directly release damage‐associated molecular patterns to amplify inflammatory responses.
Neutrophil Extracellular Traps and Liver Disease.
TLDR
There is much interest in the therapeutic potential of NET inhibition, but future clinical applications must be balanced against potential increased risk of infection.
Neutrophil Extracellular Traps: Formation and Involvement in Disease Progression.
TLDR
The purpose of this review is to highlight the molecular mechanisms of NETosis and its antimicrobial effect and a current status ofNETosis in the pathogenesis of inflammatory and autoimmune disorders has been reviewed for better understanding.
Mechanisms and disease relevance of neutrophil extracellular trap formation
TLDR
Current concepts of the mechanisms and disease relevance of NET formation are discussed and the disease relevance and clinical translatability of this unconventional cellular mechanism are discussed.
The immune regulatory role of neutrophils
TLDR
New work suggests that it is time to give greater consideration to the anti‐inflammatory role of neutrophils, such as in the control of cytokine release during sepsis.
Neutrophil extracellular traps : function in infectious and non-Infectious conditions
TLDR
Light is shed on the clearance and degradation of NETs by phagocytic cells and the involvement of several endonucleases in a cell type-specific manner, and the importance ofNETs in fungal killing is confirmed, with new evidence for a role of JAGN1 in this process.
The emerging role of neutrophilic extracellular traps in intestinal disease
TLDR
The latest knowledge on the formation mechanisms of NETs and their pathophysiological roles in a variety of intestinal diseases are summarized with the aim of providing an essential directional guidance and theoretical basis for clinical interventions in the exploration of mechanisms underlyingNETs and targeted therapies.
On the Origin of Neutrophil Extracellular Traps in COVID-19
TLDR
The aim of this review is to summarize potential inducers of NETs formation in severe COVID-19 and to discuss potential treatment options targetingNETs formation of removal.
Neutrophil Extracellular Traps Tied to Rheumatoid Arthritis: Points to Ponder
TLDR
The potential of neutrophil extracellular traps to drive the pathogenesis of rheumatoid arthritis and experimental animal models is summarized.
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TLDR
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