An emerging opportunistic infection: fatal astrovirus (VA1/HMO‐C) encephalitis in a pediatric stem cell transplant recipient

@article{Lum2016AnEO,
  title={An emerging opportunistic infection: fatal astrovirus (VA1/HMO‐C) encephalitis in a pediatric stem cell transplant recipient},
  author={Su Han Lum and Andrew Turner and Malcolm Guiver and Denise K. Bonney and Timorthy Martland and Emma Davies and Melanie Newbould and Julianne R. Brown and Sofia Morfopoulou and Judith Breuer and Robert Francis Wynn},
  journal={Transplant Infectious Disease},
  year={2016},
  volume={18},
  pages={960 - 964}
}
Neuroinvasive astrovirus (VA1‐HMO‐C) is an emerging life‐threatening infection in immunocompromised hosts. We describe an 8‐month‐old child who died of VA1/HMO‐C encephalitis following bone marrow transplantation. The diagnosis was only made post‐mortem using RNA deep sequencing of the brain. Repeat analysis of the post‐mortem brain tissue using polymerase chain reaction specific primers for VA1/HMO‐C was positive. Astrovirus VA1/HMO‐C should be included in the evaluation of patients with… 

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