An embryonic source of Ly1 but not conventional B cells.

  title={An embryonic source of Ly1 but not conventional B cells.},
  author={N W Solvason and A Lehuen and John F Kearney},
  journal={International immunology},
  volume={3 6},
Ly1+ B cells differ from conventional B cells with respect to their anatomical localization, cell surface marker expression, and antibody repertoire suggesting that they may constitute a functionally distinct subset of B cells. To determine whether Ly1+ B cells also have a developmentally distinct site of origin we grafted various fetal primordia into adult severe combined immunodeficient (scid) mice and analyzed their potential to give rise to T and B cells. We demonstrated that fetal omentum… CONTINUE READING