An eleven-base-pair sequence determines the specificity of DNA uptake in Haemophilus transformation.

@article{Danner1980AnES,
  title={An eleven-base-pair sequence determines the specificity of DNA uptake in Haemophilus transformation.},
  author={D B Danner and Robert A. Deich and K L Sisco and Hamilton O. Smith},
  journal={Gene},
  year={1980},
  volume={11 3-4},
  pages={311-8}
}
Only certain DNA fragments are taken up efficiently by component Haemophilus cells; this implies that efficient uptake requires the presence of a specific nucleotide sequence on the incoming DNA (Sisco and Smith, 1979). To determine the structure of this "uptake site", we have isolated and sequenced four small fragments of cloned H. parainfluenzae DNA which retain the ability to be taken up by cells. These fragments have a sequence of eleven base pairs in common, 5'-AAGTGCGGTCA-3' and… CONTINUE READING

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